Research - IRB

Research groups

Cellular Immunology

Group Leader:Federica Sallusto

Cellular Immunology

Group Leader:Federica Sallusto

The focus of our laboratory is the analysis of the immune response in humans using novel high throughput cell-based assays complemented with powerful analytical technologies, such as next generation sequencing, single cell transcriptomics, metabolomics and proteomics.

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Chemokines in Immunity

Group Leader: Mariagrazia Uguccioni

Chemokines in Immunity

Group Leader: Mariagrazia Uguccioni

Our research interest remains focused on cell trafficking in human physiology and pathology, with an emphasis on the mechanisms governing fine-tuning modulation of chemokine expression and activity, in order to identify novel therapeutic target for pharmacological intervention.

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Computational Structural Biology

Group Leader: Andrea Cavalli

Computational Structural Biology

Group Leader: Andrea Cavalli

The overall objective of our research is to understand the role that structure and dynamics play in the definition of the function of biomolecules.

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Immune Mechanisms

Group Leader: Greta Guarda

Immune Mechanisms

Group Leader: Greta Guarda

Our research focuses on the interplay between major histocompatibility complex (MHC) class I, cytotoxic T cells, and natural killer (NK) cells in the context of infection and cancer.

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Immune Regulation

Group Leader: Antonio Lanzavecchia

Immune Regulation

Group Leader: Antonio Lanzavecchia

Lanzavecchia’s laboratory investigates the mechanisms of antibody-mediated resistance to infectious diseases.

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Immunology and Infectious Disease

Group Leader: Davide Robbiani

Immunology and Infectious Disease

Group Leader: Davide Robbiani

Davide Robbiani studies B lymphocytes, which are crucial to immune defense because they produce infection-fighting antibodies—the key to the efficacy of most vaccines.

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Infection and Immunity

Group Leader: Santiago F. González

Infection and Immunity

Group Leader: Santiago F. González

The primary focus of the lab is to study the interface between pathogen and host.

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Molecular Immunology

Group Leader: Silvia Monticelli

Molecular Immunology

Group Leader: Silvia Monticelli

The research topic of the group concerns the study of transcriptional and post-transcriptional mechanisms of regulation of gene expression in cells of the immune system.

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Mucosal Immunology

Group Leader: Fabio Grassi

Mucosal Immunology

Group Leader: Fabio Grassi

The human gastrointestinal (GI) tract is a complex ecological niche, in which all the three domains of life (Archaea, Bacteria and Eukarya) and Viruses co-exist in close association with the host.

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Protein Folding and Quality Control

Group Leader: Maurizio Molinari

Protein Folding and Quality Control

Group Leader: Maurizio Molinari

The endoplasmic reticulum (ER) contains high concentrations of molecular chaperones and enzymes that assist maturation of newly synthesized polypeptides destined to the extracellular space, the plasma membrane and the organelles of the endocytic and secretory pathways.

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Recombination Mechanisms

Group Leader: Petr Cejka

Recombination Mechanisms

Group Leader: Petr Cejka

Deoxyribonucleic acid (DNA) stores genetic information that contains instructions for the proper development and function of all living organisms.

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Signal Transduction

Group Leader: Marcus Thelen

Signal Transduction

Group Leader: Marcus Thelen

The chemokine system is best known for its fundamental role in regulating leukocyte trafficking. Cell migration is governed by chemotactic cues that are generated by locally produced chemokines which are retained in the vicinity of the source by binding to cell surfaces, e.g. to proteoglycans.

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Structural Biology

Group Leader: Luca Varani

Structural Biology

Group Leader: Luca Varani

This group uses computational, biochemical and biophysical tools to determine the three-dimensional atomic structure of proteins and characterize their interactions with other molecules, with particular attention to antibody-antigen interactions in infectious diseases.

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Systems Immunology

Group Leader: Roger Geiger

Systems Immunology

Group Leader: Roger Geiger

T cells are key players in the immune system with the ability to detect and eliminate infected cells and tumors. We study molecular regulations underlying T cell activation and anti-tumor activity.

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Research groups

Cellular Immunology

Cellular Immunology

Chemokines in Immunity

Chemokines in Immunity

Computational Structural Biology

Computational Structural Biology

Immune Mechanisms

Immune Mechanisms

Immune Regulation

Immune Regulation

Immunology and Infectious Disease

Immunology and Infectious Disease

Infection and Immunity

Infection and Immunity

Molecular Immunology

Molecular Immunology

Mucosal Immunology

Mucosal Immunology

Protein Folding and Quality Control

Protein Folding and Quality Control

Recombination Mechanisms

Recombination Mechanisms

Signal Transduction

Signal Transduction

Structural Biology

Structural Biology

Systems Immunology

Systems Immunology

Institute for Research in Biomedicine

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