Molinari Maurizio, PhD

Publications -> 19696

• Site of Action and Cellular Effects Caused by the VacA Cytotoxin Released by Helicobacter pylori
  de Bernard, M. Papini, E. Molinari, M. Telford, J. R. Rappuoli, R. Montecucco, C.
  in Bacterial Toxins: A comprehensive Sourcebook (1970) Vol. pp
  
• Deep learning approach for quantification of organelles and misfolded polypeptides delivery within degradative compartments
  Morone, D. Marazza, A. Bergmann, T. J. Molinari, M.
  in Mol Biol Cell (2020) Vol. ppmbcE20040269
  
• Mechanistic insights in recov-ER-phagy: micro-ER-phagy to recover from stress
  Loi, M. Molinari, M.
  in Autophagy (2020) Vol.16 pp385-386
  
• Endoplasmic Reticulum and Lysosomal Quality Control of Four Nonsense Mutants of Iduronate 2-Sulfatase Linked to Hunter’s Syndrome
  Marazza, A. Galli, C. Fasana, E. Burda, P. Fassi, E. M. A. Baumgartner, M. Cavalli, A. Molinari, M.
  in DNA Cell Biol (2020) Vol.39 pp226-234
  
• ESCRT-III-driven piecemeal micro-ER-phagy remodels the ER during recovery from ER stress
  Loi, M. Raimondi, A. Morone, D.
  in Nat Commun (2019) Vol.10 pp5058
  
• Proteasomal and lysosomal clearance of faulty secretory proteins: ER-associated degradation (ERAD) and ER-to-lysosome-associated degradation (ERLAD) pathways
  Fregno, I. Molinari, M.
  in Crit Rev Biochem Mol Biol (2019) Vol. pp1-11
  
• Schwann cells ER-associated degradation contributes to myelin maintenance in adult nerves and limits demyelination in CMT1B mice
  Volpi, V. G. Ferri, C. Fregno, I. Bianchi, F. Scapin, C. Pettinato, E. Solda, T. Feltri, M. L. Molinari, M. Wrabetz, L. D'Antonio, M.
  in PLoS Genet (2019) Vol.15 ppe1008069
  
• A selective ER-phagy exerts procollagen quality control via a Calnexin-FAM134B complex
  Forrester, A. De Leonibus, C. Grumati, P. Piemontese, M. Staiano, L. Fregno, I. Raimondi, A. Marazza, A. Bruno, G. Iavazzo, M. Intartaglia, D. Seczynska, M. van Anken, E. Conte, I. De Matteis, M. A. Dikic, I. Molinari, M. Settembre, C.
  in EMBO J (2018) Vol.38 ppe99847
  
• ER-to-lysosome-associated degradation of proteasome-resistant ATZ polymers occurs via receptor-mediated vesicular transport
  Fregno, I. Fasana, E. Bergmann, T. J. Loi, M. Solda, T. Galli, C. D'Antuono, R. Morone, D. Danieli, A. Paganetti, P. van Anken, E. Molinari, M.
  in EMBO J (2018) Vol.37 ppe99259
  
• Three branches to rule them all? UPR signaling in response to chemically- versus misfolded proteins-induced ER stress
  Bergmann, T. J. Molinari, M.
  in Biol Cell (2018) Vol.110 pp197-204
  
• The reductase TMX1 contributes to ERAD by preferentially acting on membrane-associated folding-defective polypeptides
  Guerra, C. Brambilla Pisoni, G. Solda, T.
  in Biochem Biophys Res Commun (2018) Vol. pp938 - 943
  
• Eat it right: ER-phagy and recovER-phagy
  Loi, M. Fregno, I. Guerra, C.
  in Biochem Soc Trans (2018) Vol. pp699–706
  
• Endoplasmic reticulum turnover: ER-phagy and other flavors in selective and non-selective ER clearance
  Fregno, I. Molinari, M.
  in F1000Res (2018) Vol.7 pp454
  
• Chemical stresses fail to mimic the unfolded protein response resulting from luminal load with unfolded polypeptides
  Bergmann, T. J. Fregno, I. Fumagalli, F. Bertoni, F. Boersema, P. J. Picotti, P. Molinari, M.
  in J Biol Chem (2018) Vol.293 pp5600-5612
  
• Role of SEC62 in ER maintenance: A link with ER stress tolerance in SEC62-overexpressing tumors?
  Bergmann, T. J. Fumagalli, F. Loi, M.
  in Mol Cell Oncol (2017) Vol.4 ppe1264351
  
• Quality control mechanisms of protein biogenesis: proteostasis dies hard
  Bergmann, T. J. Brambilla Pisoni, G. Molinari, M.
  in AIMS Biophysics (2016) Vol.3 pp456-478
  
• Translocon component Sec62 acts in endoplasmic reticulum turnover during stress recovery
  Fumagalli, F. Noack, J. Bergmann, T. J. Pisoni, G. B. Fasana, E. Fregno, I. Galli, C. Loi, M. Solda, T. D'Antuono, R. Raimondi, A. Jung, M. Melnyk, A. Schorr, S. Schreiber, A. Simonelli, L. Varani, L. Wilson-Zbinden, C. Zerbe, O. Hofmann, K. Peter, M. Quadroni, M. Zimmermann, R. Molinari, M.
  in Nat Cell Biol (2016) Vol.18 pp1173-1184
  Fumagalli, F. , Noack J. and Bergmann T. contributed equally to this work. * Recommended by the Faculty of 1000
• Post ER Quality Control: A Role for UDP-Glucose:Glycoprotein Glucosyl Transferase and p97
  Fregno, I. Molinari, M.
  in J Rare Dis Res & Treatment (2016) Vol.1 pp40-42
  
• Five Questions (with their Answers) on ER-Associated Degradation
  Brambilla Pisoni, G. Molinari, M.
  in Traffic (2016) Vol.17 pp341-50
  
• Guidelines for the use and interpretation of assays for monitoring autophagy
  Klionsky, D. J. Molinari, M. et al.
  in Autophagy (2016) Vol.12 pp1-222
  
• Division of labor among oxidoreductases: TMX1 preferentially acts on transmembrane polypeptides
  Pisoni, G. B. Ruddock, L. W. Bulleid, N.
  in Mol Biol Cell (2015) Vol.26 pp3390-400
  
• The Protein-disulfide Isomerase ERp57 Regulates the Steady-state Levels of the Prion Protein
  Torres, M. Medinas, D. B. Matamala, J. M. Cornejo, V. H. Solda, T. Andreu, C. Rozas, P. Matus, S. Munoz, N. Vergara, C. Cartier, L. Soto, C. Molinari, M. Hetz, C.
  in J Biol Chem (2015) Vol.290 pp23631-45
  
• Glycoprotein maturation and quality control
  Molinari, M. Hebert, D. N.
  in Semin Cell Dev Biol (2015) Vol.41 pp70
  
• A novel UGGT1 and p97-dependent checkpoint for native ectodomains with ionizable intramembrane residue
  Merulla, J. Solda, T. Molinari, M.
  in Mol Biol Cell (2015) Vol.26 pp1532-42
  * Recommended by the Faculty of 1000
• N-linked sugar-regulated protein folding and quality control in the ER
  Tannous, A. Pisoni, G. B. Hebert, D. N.
  in Semin Cell Dev Biol (2014) Vol.41 pp79-89
  
• Protein trafficking: RESETting proteostasis
  Noack, J. Molinari, M.
  in Nat Chem Biol (2014) Vol.10 pp881-2
  
• Proteostasis: Bad news and good news from the endoplasmic reticulum
  Noack, J. Brambilla Pisoni, G. Molinari, M.
  in Swiss Med Wkly (2014) Vol.144 ppw14001
  
• How viruses hijack the ERAD tuning machinery
  Noack, J. Bernasconi, R. Molinari, M.
  in J Virol (2014) Vol.88 pp10272-5
  Correction to the paper can be found here: http://jvi.asm.org/content/89/7/4040.long
• Non-Lipidated LC3 is Essential for Mouse Hepatitis Virus Infection
  Noack, J. Bernasconi, R. Molinari, M.
  in Autophagy (2014) Vol.2 pp129-136
  
• Transgenic expression of beta1 antibody in brain neurons impairs age-dependent amyloid deposition in APP23 mice
  Paganetti, P. Reichwald, J. Bleckmann, D. Ammaturo, D. Barske, C. Danner, S. Molinari, M. Muller, M. Papin, S. Rabe, S. Schmid, P. Staufenbiel, M.
  in Neurobiol Aging (2013) Vol.34 pp2866-78
  
• UDP-glucose:glycoprotein glucosyltransferase (UGGT1) promotes substrate solubility in the endoplasmic reticulum
  Ferris, S. P. Jaber, N. S. Molinari, M. Kaufman, R. J.
  in Mol Biol Cell (2013) Vol.24 pp2597-2608
  
• Specificity and regulation of the endoplasmic reticulum-associated degradation machinery
  Merulla, J. Fasana, E. Solda, T.
  in Traffic (2013) Vol.14 pp767-77
  
• Flagging and docking: dual roles for N-glycans in protein quality control and cellular proteostasis
  Hebert, D. N. Molinari, M.
  in Trends Biochem Sci (2012) Vol.37 pp404-10
  
• Unconventional roles of nonlipidated LC3 in ERAD tuning and coronavirus infection
  Bernasconi, R. Noack, J. Molinari, M.
  in Autophagy (2012) Vol.8 pp1534-6
  
• Unconventional Use of LC3 by Coronaviruses through the Alleged Subversion of the ERAD Tuning Pathway
  Reggiori, F. de Haan, C. A. Molinari, M.
  in Viruses (2011) Vol.3 pp1610-23
  
• Malectin Participates in a Backup Glycoprotein Quality Control Pathway in the Mammalian ER
  Galli, C. Bernasconi, R. Solda, T. Molinari, M.
  in PLoS One (2011) Vol.6 ppe16304
  
• ERAD and ERAD tuning: disposal of cargo and of ERAD regulators from the mammalian ER
  Bernasconi, R. Molinari, M.
  in Curr Opin Cell Biol (2010) Vol.23 pp176-183
  
• Cyclosporine a-sensitive, cyclophilin B-dependent endoplasmic reticulum-associated degradation
  Bernasconi, R. Solda, T. Galli, C. Luban, J. Molinari, M.
  in PLoS One (2010) Vol.5 ppe13008
  
• Autophagy-independent LC3 function in vesicular traffic
  de Haan, C. A. Molinari, M. Reggiori, F.
  in Autophagy (2010) Vol.6 pp994-6
  
• Coronaviruses Hijack the LC3-I-positive EDEMosomes, ER-derived vesicles exporting short-lived ERAD regulators, for replication
  Reggiori, F. Monastyrska, I. Verheije, M. H. Ulasli, M. Bianchi, S. Bernasconi, R. de Haan, C. A. Molinari, M.
  in Cell Host Microbe (2010) Vol.7 pp500-8
  * Highlights in Cell Host & Microbe 7, 424-426; Editors’ Choice in Science 329, 14; Leading Edge, Microbiology Select in Cell 142, 5; Recommended by the Faculty of 1000
• Stringent requirement for HRD1, SEL1L, and OS-9/XTP3-B for disposal of ERAD-LS substrates
  Bernasconi, R. Galli, C. Calanca, V. Molinari, M.
  in J Cell Biol (2010) Vol.188 pp223-35
  * Highlights in J. Cell Biol 188, 176
• ERAD substrates: which way out?
  Hebert, D. N. Bernasconi, R. Molinari, M.
  in Semin Cell Dev Biol (2009) Vol.21 pp526-32
  
• N-glycan structures: recognition and processing in the ER
  Aebi, M. Bernasconi, R. Clerc, S.
  in Trends Biochem Sci (2009) Vol.35 pp74-82
  
• The endoplasmic reticulum crossroads for newly synthesized polypeptide chains
  Cali, T. Vanoni, O. Molinari, M.
  in Prog Mol Biol Transl Sci (2009) Vol.83 pp135-79
  
• Consequences of individual N-glycan deletions and of proteasomal inhibition on secretion of active BACE
  Vanoni, O. Paganetti, P. Molinari, M.
  in Mol Biol Cell (2008) Vol.19 pp4086-98
  
• ER-Associated Folding and Degradation: Learning From Yeast?
  Bernasconi, R. Molinari, M.
  in Protein misfolding (2008) Vol. pp
  
• Segregation and rapid turnover of EDEM1 by an autophagy-like mechanism modulates standard ERAD and folding activities
  Cali, T. Galli, C. Olivari, S.
  in Biochem Biophys Res Commun (2008) Vol.371 pp405-10
  
• A dual task for the Xbp1-responsive OS-9 variants in the mammalian endoplasmic reticulum: inhibiting secretion of misfolded protein conformers and enhancing their disposal
  Bernasconi, R. Pertel, T. Luban, J.
  in J Biol Chem (2008) Vol.283 pp16446-54
  
• In and out of the ER: protein folding, quality control, degradation, and related human diseases
  Hebert, D. N. Molinari, M.
  in Physiol Rev (2007) Vol.87 pp1377-408
  
• Substrate-specific requirements for UGT1-dependent release from calnexin
  Solda, T. Galli, C. Kaufman, R. J.
  in Mol Cell (2007) Vol.27 pp238-49
  
• N-glycan structure dictates extension of protein folding or onset of disposal
  Molinari, M.
  in Nat Chem Biol (2007) Vol.3 pp313-20
  
• Glycoprotein folding and the role of EDEM1, EDEM2 and EDEM3 in degradation of folding-defective glycoproteins
  Olivari, S. Molinari, M.
  in FEBS Lett (2007) Vol.581 pp3658-64
  
• N-glycan processing in ER quality control
  Ruddock, L. W. Molinari, M.
  in J Cell Sci (2006) Vol.119 pp4373-80
  
• Microbiology: death of a chaperone
  Montecucco, C. Molinari, M.
  in Nature (2006) Vol.443 pp511-2
  
• EDEM1 regulates ER-associated degradation by accelerating de-mannosylation of folding-defective polypeptides and by inhibiting their covalent aggregation
  Olivari, S. Cali, T. Salo, K. E. Ruddock, L. W. Molinari, M.
  in Biochem Biophys Res Commun (2006) Vol.349 pp1278-84
  * Recommended by the Faculty of 1000
• N-linked glycan recognition and processing: the molecular basis of endoplasmic reticulum quality control
  Moremen, K. W. Molinari, M.
  in Curr Opin Struct Biol (2006) Vol.16 pp592-9
  
• The secretory capacity of a cell depends on the efficiency of endoplasmic reticulum-associated degradation
  Molinari, M. Sitia, R.
  in Curr Top Microbiol Immunol (2006) Vol.300 pp1-15
  
• Consequences of ERp57 deletion on oxidative folding of obligate and facultative clients of the calnexin cycle
  Solda, T. Garbi, N. Hammerling, G. J.
  in J Biol Chem (2006) Vol.281 pp6219-26
  
• Persistent glycoprotein misfolding activates the glucosidase II/UGT1-driven calnexin cycle to delay aggregation and loss of folding competence
  Molinari, M. Galli, C. Vanoni, O. Kaufman, R. J.
  in Mol Cell (2005) Vol.20 pp503-12
  
• The use of calnexin and calreticulin by cellular and viral glycoproteins
  Pieren, M. Galli, C. Denzel, A.
  in J Biol Chem (2005) Vol.280 pp28265-71
  
• The glycan code of the endoplasmic reticulum: asparagine-linked carbohydrates as protein maturation and quality-control tags
  Hebert, D. N. Garman, S. C. Molinari, M.
  in Trends Cell Biol (2005) Vol.15 pp364-70
  
• beta-site specific intrabodies to decrease and prevent generation of Alzheimer’s Abeta peptide
  Paganetti, P. Calanca, V. Galli, C. Molinari, M.
  in J Cell Biol (2005) Vol.168 pp863-8
  * Comments in NIBR Science Summer 2005
• Degradation of trafficking-defective long QT syndrome type II mutant channels by the ubiquitin-proteasome pathway
  Gong, Q. Keeney, D. R. Molinari, M.
  in J Biol Chem (2005) Vol.280 pp19419-25
  
• Analyzing folding and degradation of metabolically labelled polypeptides by conventional and diagonal sodium dodecyl sulfate-polyacrylamide gel electrophoresis
  Solda, T. Olivari, S. Molinari, M.
  in Biol Proced Online (2005) Vol.7 pp136-43
  
• A novel stress-induced EDEM variant regulating endoplasmic reticulum-associated glycoprotein degradation
  Olivari, S. Galli, C. Alanen, H. Molinari, M.
  in J Biol Chem (2004) Vol.280 pp2424-8
  
• EDEM contributes to maintenance of protein folding efficiency and secretory capacity
  Eriksson, K. K. Vago, R. Calanca, V. Paganetti, P. Molinari, M.
  in J Biol Chem (2004) Vol.279 pp44600-5
  
• Endoplasmic Reticulum-Associated Protein Degradation
  Molinari, M.
  in Encyclopedia of Biological Chemistry (2004) Vol.2 pp
  
• The Protein Factory
  Molinari, M.
  in Protocols of the 30th Seminars of Biological Evolution (2004) Vol.108 pp117-122
  
• Contrasting functions of calreticulin and calnexin in glycoprotein folding and ER quality control
  Molinari, M. Eriksson, K. K. Calanca, V. Cresswell, P. Michalak, M. Helenius, A.
  in Mol Cell (2004) Vol.13 pp125-35
  
• Role of EDEM in the release of misfolded glycoproteins from the calnexin cycle
  Molinari, M. Calanca, V. Galli, C. Paganetti, P.
  in Science (2003) Vol.299 pp1397-400
  * Comments in Science 299, 1330-1331; Nature Reviews Molecular and Cellular Biology, 4, 259; Nature Structural and Molecular Biology, 10, 319-321; Recommended by the Faculty of 1000
• Early postnatal death and motor disorders in mice congenitally deficient in calnexin expression
  Denzel, A. Molinari, M. Trigueros, C. Velmurgan, S. Brown, S. Stamp, G. Owen, M. J.
  in Mol Cell Biol (2002) Vol.22 pp7398-404
  
• Sequential assistance of molecular chaperones and transient formation of covalent complexes during protein degradation from the ER
  Molinari, M. Galli, C. Piccaluga, V. Paganetti, P.
  in J Cell Biol (2002) Vol.158 pp247-57
  
• The disulphide bonds in the catalytic domain of BACE are critical but not essential for amyloid precursor protein processing activity
  Fischer, F. Molinari, M. Bodendorf, U.
  in J Neurochem (2002) Vol.80 pp1079-88
  
• Analyzing cotranslational protein folding and disulfide formation by diagonal sodium dodecyl sulfate-polyacrylamide gel electrophoresis
  Molinari, M. Helenius, A.
  in Methods Enzymol (2002) Vol.348 pp35-42
  
• Folding of viral glycoproteins in the endoplasmic reticulum
  Molinari, M.
  in Virus Res (2002) Vol.82 pp83-6
  
• Role of Molecular Chaperones in Viral Glycoprotein Folding
  Molinari, M. Helenius, A.
  in Intracellular and persistent infections, Nobel Symposium (2001) Vol.106 pp
  
• Affinity purification of mu-calpain from erythrocytes on an immobilized peptide from the plasma membrane calcium pump. Some studies on erythrocyte mu-calpain
  Molinari, M. Carafoli, E.
  in Methods Mol Biol (2000) Vol.144 pp41-6
  
• Chaperone selection during glycoprotein translocation into the endoplasmic reticulum
  Molinari, M. Helenius, A.
  in Science (2000) Vol.288 pp331-3
  
• Setting the standards: quality control in the secretory pathway
  Ellgaard, L. Molinari, M. Helenius, A.
  in Science (1999) Vol.286 pp1882-8
  
• Glycoproteins form mixed disulphides with oxidoreductases during folding in living cells
  Molinari, M. Helenius, A.
  in Nature (1999) Vol.402 pp90-3
  * News and Views in Nature 402, 27-29
• The Helicobacter pylori neutrophil-activating protein is an iron-binding protein with dodecameric structure
  Tonello, F. Dundon, W. G. Satin, B. Tognon, G. Grandi, G. Del Giudice, G. Rappuoli, R. Montecucco, C.
  in Mol Microbiol (1999) Vol.34 pp238-46
  
• Action site and cellular effects of cytotoxin VacA produced by Helicobacter pylori
  Papini, E. Satin, B. de Bernard, M. Arico, B. Galli, C. Telford, J. R. Rappuoli, R. Montecucco, C.
  in Folia Microbiol (Praha) (1998) Vol.43 pp279-84
  
• The acid activation of Helicobacter pylori toxin VacA: structural and membrane binding studies
  Molinari, M. Galli, C. de Bernard, M. Ruysschaert, J. M. Rappuoli, R. Montecucco, C.
  in Biochem Biophys Res Commun (1998) Vol.248 pp334-40
  
• Calpain: a protease in search of a function?
  Carafoli, E. Molinari, M.
  in Biochem Biophys Res Commun (1998) Vol.247 pp193-203
  
• Selective inhibition of Ii-dependent antigen presentation by Helicobacter pylori toxin VacA
  Molinari, M. Salio, M. Galli, C. Rappuoli, R. Lanzavecchia, A. Montecucco, C.
  in J Exp Med (1998) Vol.187 pp135-40
  
• Vacuoles induced by Helicobacter pylori toxin contain both late endosomal and lysosomal markers
  Molinari, M. Galli, C. Norais, N. Rappuoli, R. Luzio, J. P. Montecucco, C.
  in J Biol Chem (1997) Vol.272 pp25339-44
  
• Expression of the VacA Cytotoxin of Helicobacter pylori in the Cell Cytosol and Alteration of Membrane Trafficking
  de Bernard, M. Papini, E. Molinari, M. Satin, B. Galli, C. Telford, J. R. Rappuoli, R. Montecucco, C.
  in Acta Med. Rom. (1997) Vol.35 pp625-633
  
• Calpain: a cytosolic proteinase active at the membranes
  Molinari, M. Carafoli, E.
  in J Membr Biol (1997) Vol.156 pp1-8
  
• Purification of active calpain by affinity chromatography on an immobilized peptide inhibitor
  Anagli, J. Vilei, E. M. Molinari, M. Carafoli, E.
  in Eur J Biochem (1996) Vol.241 pp948-54
  
• Purification of mu-calpain by a novel affinity chromatography approach. New insights into the mechanism of the interaction of the protease with targets
  Molinari, M. Maki, M. Carafoli, E.
  in J Biol Chem (1995) Vol.270 pp14576-81
  
• PEST sequences do not influence substrate susceptibility to calpain proteolysis
  Molinari, M. Anagli, J. Carafoli, E.
  in J Biol Chem (1995) Vol.270 pp2032-5
  
• Ca(2+)-activated neutral protease is active in the erythrocyte membrane in its nonautolyzed 80-kDa form
  Molinari, M. Anagli, J. Carafoli, E.
  in J Biol Chem (1994) Vol.269 pp27992-5