Cejka Petr, PhD

Publications -> 20805

• The iron-sulphur cluster in human DNA2 is required for all biochemical activities of DNA2
  Mariotti, L. Wild, S. Brunoldi, G. Piceni, A. Ceppi, I. Kummer, S. Lutz, R. E. Cejka, P. Gari, K.
  in Commun Biol (2020) Vol.3 pp322
  
• MCM8IP activates the MCM8-9 helicase to promote DNA synthesis and homologous recombination upon DNA damage
  Huang, J. W. Acharya, A. Taglialatela, A. Nambiar, T. S. Cuella-Martin, R. Leuzzi, G. Hayward, S. B. Joseph, S. A. Brunette, G. J. Anand, R. Soni, R. K. Clark, N. L. Bernstein, K. A. Cejka, P. Ciccia, A.
  in Nat Commun (2020) Vol.11 pp2948
  
• Phosphorylation of the RecQ Helicase Sgs1/BLM Controls Its DNA Unwinding Activity during Meiosis and Mitosis
  Grigaitis, R. Ranjha, L. Wild, P. Kasaciunaite, K. Ceppi, I. Kissling, V. Henggeler, A. Susperregui, A. Peter, M. Seidel, R. Cejka, P. Matos, J.
  in Dev Cell (2020) Vol. pp
  
• The MRE11 complex: A versatile toolkit for the repair of broken DNA
  Reginato, G. Cejka, P.
  in DNA Repair (Amst) (2020) Vol.91-92 pp102869
  
• The internal region of CtIP negatively regulates DNA end resection
  Howard, S. M. Ceppi, I. Anand, R. Cejka, P.
  in Nucleic Acids Res (2020) Vol. pp
  
• CtIP promotes the motor activity of DNA2 to accelerate long-range DNA end resection
  Ceppi, I. Howard, S. M. Kasaciunaite, K. Anand, R. Seidel, R. Cejka, P.
  in Proc Natl Acad Sci U S A (2020) Vol.117 pp8859-8869
  
• Regulated Proteolysis of MutSgamma Controls Meiotic Crossing Over
  He, W. Rao, Hbdp Tang, S. Kulkarni, D. S. Ma, Y. Chang, M. A. W. Hall, C. Bragg, J. W. Manasca, H. S. Baker, C. Verhees, G. F. Ranjha, L. Chen, X. Hollingsworth, N. M. Cejka, P. Hunter, N.
  in Mol Cell (2020) Vol.78 pp168-183 e5
  
• Competing interaction partners modulate the activity of Sgs1 helicase during DNA end resection
  Kasaciunaite, K. Fettes, F. Levikova, M. Anand, R. Cejka, P. Seidel, R.
  in EMBO J (2019) Vol.38 ppe101516
  
• Sumoylation regulates the stability and nuclease activity of Saccharomyces cerevisiae Dna2
  Ranjha, L. Levikova, M. Altmannova, V. Cejka, P.
  in Commun Biol (2019) Vol.2 pp174
  
• Seeing is believing: DNA zipping promotes DNA repair
  Cejka, P.
  in J Biol Chem (2019) Vol.294 pp3321-3322
  
• Stepwise 5′ DNA end-specific resection of DNA breaks by the Mre11-Rad50-Xrs2 and Sae2 nuclease ensemble
  Cannavo, E. Reginato, G. Cejka, P.
  in Proc Natl Acad Sci U S A (2019) Vol.116 pp5505-5513
  
• NBS1 promotes the endonuclease activity of the MRE11-RAD50 complex by sensing CtIP phosphorylation
  Anand, R. Jasrotia, A. Bundschuh, D. Ranjha, L. Stucki, M. Cejka, P.
  in EMBO J (2019) Vol.38 ppe101005
  
• BRCA2 controls DNA:RNA hybrid level at DSBs by mediating RNase H2 recruitment
  D'Alessandro, G. Whelan, D. R. Howard, S. M. Renaudin, X. Adamowicz, M. Iannelli, F. Jones-Weinert, C. W. Lee, M. Matti, V. Lee, W. T. C. Morten, M. J. Venkitaraman, A. R. Cejka, P. Rothenberg, E. d'Adda di Fagagna, F.
  in Nat Commun (2018) Vol.9 pp5376
  
• Regulatory control of DNA end resection by Sae2 phosphorylation
  Cannavo, E. Johnson, D. Andres, S. N. Reinert, J. K. Garcia, V. Erie, D. A. Hess, D. Thoma, N. H. Enchev, R. I. Peter, M. Williams, R. S. Neale, M. J. Cejka, P.
  in Nat Commun (2018) Vol.9 pp4016
  
• A meiotic XPF-ERCC1-like complex recognizes joint molecule recombination intermediates to promote crossover formation
  De Muyt, A. Pyatnitskaya, A. Andreani, J. Ramus, C. Laureau, R. Fernandez-Vega, A. Holoch, D. Girard, E. Govin, J. Margueron, R. Coute, Y. Cejka, P. Guerois, R. Borde, V.
  in Genes Dev (2018) Vol.32 pp283-296
  
• Methods to Study DNA End Resection I: Recombinant Protein Purification
  Anand, R. Pinto, C. Cejka, P.
  in Methods Enzymol (2018) Vol.600 pp25-66
  
• Main steps in DNA double-strand break repair: an introduction to homologous recombination and related processes
  Ranjha, L. Howard, S. M. Cejka, P.
  in Chromosoma (2018) Vol.127 pp187-214
  
• Methods to Study DNA End Resection II: Biochemical Reconstitution Assays
  Pinto, C. Anand, R. Cejka, P.
  in Methods Enzymol (2018) Vol.600 pp67-106
  
• Physiological protein blocks direct the Mre11-Rad50-Xrs2 and Sae2 nuclease complex to initiate DNA end resection
  Reginato, G. Cannavo, E. Cejka, P.
  in Genes Dev (2017) Vol.31 pp2325-2330
  
• Biochemistry: Complex assistance for DNA invasion
  Cejka, P.
  in Nature (2017) Vol.550 pp342-343
  
• SAMHD1 Promotes DNA End Resection to Facilitate DNA Repair by Homologous Recombination
  Daddacha, W. Koyen, A. E. Bastien, A. J. Dhere, V. R. Nabeta, G. N. Connolly, E. C. Werner, E. Madden, M. Z. Daly, M. B. Minten, E. V. Whelan, D. R. Schlafstein, A. J. Zhang, H. Anand, R. Doronio, C. Withers, A. E. Shepard, C. Sundaram, R. K. Deng, X. Dynan, W. S. Wang, Y. Bindra, R. S. Cejka, P. Rothenberg, E. Doetsch, P. W. Kim, B. Yu, D. S.
  in Cell Rep (2017) Vol.20 pp1921-1935
  
• The motor activity of DNA2 functions as an ssDNA translocase to promote DNA end resection
  Levikova, M. Pinto, C. Cejka, P.
  in Genes Dev (2017) Vol.31 pp493-502
  
• The Mre11-Nbs1 Interface Is Essential for Viability and Tumor Suppression
  Kim, J. H. Grosbart, M. Anand, R. Cejka, P. Petrini, J. H.
  in Cell Rep (2017) Vol.18 pp496-507
  
• Concerted action of the MutLbeta heterodimer and Mer3 helicase regulates the global extent of meiotic gene conversion
  Duroc, Y. Kumar, R. Ranjha, L. Guerois, R. Md Muntaz, K. Marsolier-Kergoat, M. C. Dingli, F. Laureau, R. Loew, D. Llorente, B. Charbonnier, J. B. Cejka, P. Borde, V.
  in Elife (2017) Vol.6 ppe21900
  
• Phosphorylated CtIP Functions as a Co-factor of the MRE11-RAD50-NBS1 Endonuclease in DNA End Resection
  Anand, R. Ranjha, L. Cannavo, E. Cejka, P.
  in Mol Cell (2016) Vol.64 pp940-950
  
• The MMS22L-TONSL heterodimer directly promotes RAD51-dependent recombination upon replication stress
  Piwko, W. Mlejnkova, L. J. Mutreja, K. Stafa, D. Smirnov, A. Brodersen, M. M. Zellweger, R. Sturzenegger, A. Janscak, P. Lopes, M. Peter, M. Cejka, P.
  in EMBO J (2016) Vol.35 pp2584-2601
  
• Replication intermediates that escape Dna2 activity are processed by Holliday junction resolvase Yen1
  Olmezer, G. Levikova, M. Klein, D. Fontana, G. A. Cejka, P. Rass, U.
  in Nat Commun (2016) Vol.7 pp13157
  
• Xrs2 Dependent and Independent Functions of the Mre11-Rad50 Complex
  Oh, J. Al-Zain, A. Cannavo, E. Cejka, P. Symington, L. S.
  in Mol Cell (2016) Vol.64 pp405-415
  
• Human DNA2 possesses a cryptic DNA unwinding activity that functionally integrates with BLM or WRN helicases
  Pinto, C. Kasaciunaite, K. Seidel, R. Cejka, P.
  in Elife (2016) Vol.5 ppe18574
  
• Force regulated dynamics of RPA on a DNA fork
  Kemmerich, F. E. Daldrop, P. Pinto, C. Cejka, P. Seidel, R.
  in Nucleic Acids Res (2016) Vol.44 pp5837-48
  
• RECQL4 Promotes DNA End Resection in Repair of DNA Double-Strand Breaks
  Lu, H. Shamanna, R. A. Keijzers, G. Rasmussen, L. J. Cejka, P. Croteau, D. L. Bohr, V. A.
  in Cell Rep (2016) Vol.16 pp161-73
  
• DNA End Resection: Nucleases Team Up with the Right Partners to Initiate Homologous Recombination
  Cejka, P.
  in J Biol Chem (2015) Vol.290 pp22931-8
  
• The Saccharomyces cerevisiae Dna2 can function as a sole nuclease in the processing of Okazaki fragments in DNA replication
  Levikova, M. Cejka, P.
  in Nucleic Acids Res (2015) Vol.43 pp7888-97
  
• Top3-Rmi1 dissolve Rad51-mediated D loops by a topoisomerase-based mechanism
  Fasching, C. L. Cejka, P. Kowalczykowski, S. C. Heyer, W. D.
  in Mol Cell (2015) Vol.57 pp595-606
  
• Sae2 promotes dsDNA endonuclease activity within Mre11-Rad50-Xrs2 to resect DNA breaks
  Cannavo, E. Cejka, P.
  in Nature (2014) Vol.514 pp122-5
  
• DNA2 cooperates with the WRN and BLM RecQ helicases to mediate long-range DNA end resection in human cells
  Sturzenegger, A. Burdova, K. Kanagaraj, R. Pinto, C. Cejka, P. Janscak, P.
  in J Biol Chem (2014) Vol.289 pp27314-26
  
• Structural and mechanistic insight into Holliday-junction dissolution by topoisomerase IIIalpha and RMI1
  Bocquet, N. Bizard, A. H. Abdulrahman, W. Faty, M. Cavadini, S. Bunker, R. D. Kowalczykowski, S. C. Cejka, P. Hickson, I. D. Thoma, N. H.
  in Nat Struct Mol Biol (2014) Vol.21 pp261-8
  
• The Saccharomyces cerevisiae Mlh1-Mlh3 heterodimer is an endonuclease that preferentially binds to Holliday junctions
  Ranjha, L. Anand, R. Cejka, P.
  in J Biol Chem (2014) Vol.289 pp5674-86
  
• Nuclease activity of Saccharomyces cerevisiae Dna2 inhibits its potent DNA helicase activity
  Levikova, M. Klaue, D. Seidel, R. Cejka, P.
  in Proc Natl Acad Sci U S A (2013) Vol.110 ppE1992-2001
  
• Pif1 family helicases suppress genome instability at G-quadruplex motifs
  Paeschke, K. Bochman, M. L. Garcia, P. D. Cejka, P. Friedman, K. L. Kowalczykowski, S. C. Zakian, V. A.
  in Nature (2013) Vol.497 pp458-62
  
• Ribonucleotides misincorporated into DNA act as strand-discrimination signals in eukaryotic mismatch repair
  Ghodgaonkar, M. M. Lazzaro, F. Olivera-Pimentel, M. Cejka, P. Reijns, M. A. Jackson, A. P. Plevani, P. Muzi-Falconi, M. Jiricny, J.
  in Mol Cell (2013) Vol.50 pp323-32
  
• Relationship of DNA degradation by Saccharomyces cerevisiae exonuclease 1 and its stimulation by RPA and Mre11-Rad50-Xrs2 to DNA end resection
  Cannavo, E. Cejka, P. Kowalczykowski, S. C.
  in Proc Natl Acad Sci U S A (2013) Vol.110 ppE1661-8
  
• Decatenation of DNA by the S. cerevisiae Sgs1-Top3-Rmi1 and RPA complex: a mechanism for disentangling chromosomes
  Cejka, P. Plank, J. L. Dombrowski, C. C. Kowalczykowski, S. C.
  in Mol Cell (2012) Vol.47 pp886-96
  * Recommended by the Faculty of 1000
• Rmi1 stimulates decatenation of double Holliday junctions during dissolution by Sgs1-Top3
  Cejka, P. Plank, J. L. Bachrati, C. Z. Kowalczykowski, S. C.
  in Nat Struct Mol Biol (2010) Vol.17 pp1377-82
  
• DNA end resection by Dna2-Sgs1-RPA and its stimulation by Top3-Rmi1 and Mre11-Rad50-Xrs2
  Cejka, P. Cannavo, E. Polaczek, P. Pokharel, S. Campbell, J. L. Kowalczykowski, S. C.
  in Nature (2010) Vol.467 pp112-6
  
• The full-length Saccharomyces cerevisiae Sgs1 protein is a vigorous DNA helicase that preferentially unwinds holliday junctions
  Cejka, P. Kowalczykowski, S. C.
  in J Biol Chem (2010) Vol.285 pp8290-301
  
• Interplay of DNA repair pathways controls methylation damage toxicity in Saccharomyces cerevisiae
  Cejka, P. Jiricny, J.
  in Genetics (2008) Vol.179 pp1835-44
  
• Expression of the MutL homologue hMLH3 in human cells and its role in DNA mismatch repair
  Cannavo, E. Marra, G. Sabates-Bellver, J. Lipkin, S. M. Fischer, F. Cejka, P. Jiricny, J.
  in Cancer Res (2005) Vol.65 pp10759-66
  
• Homologous recombination rescues mismatch-repair-dependent cytotoxicity of S(N)1-type methylating agents in S. cerevisiae
  Cejka, P. Mojas, N. Gillet, L. Jiricny, J.
  in Curr Biol (2005) Vol.15 pp1395-400
  
• Somatic hypermutation and mismatch repair in non-B cells
  Klasen, M. Spillmann, F. J. Marra, G. Wabl, M.
  in Eur J Immunol (2005) Vol.35 pp2222-9
  
• High doses of SN1 type methylating agents activate DNA damage signaling cascades that are largely independent of mismatch repair
  Stojic, L. Cejka, P. Jiricny, J.
  in Cell Cycle (2005) Vol.4 pp473-7
  
• Mismatch repair-dependent G2 checkpoint induced by low doses of SN1 type methylating agents requires the ATR kinase
  Stojic, L. Mojas, N. Cejka, P. Ferrari, S. Marra, G. Jiricny, J.
  in Genes Dev (2004) Vol.18 pp1331-44
  
• Dependence of the cytotoxicity of DNA-damaging agents on the mismatch repair status of human cells
  Papouli, E. Cejka, P. Jiricny, J.
  in Cancer Res (2004) Vol.64 pp3391-4
  
• Is mismatch repair really required for ionizing radiation-induced DNA damage signaling?
  Cejka, P. Stojic, L. Marra, G.
  in Nat Genet (2004) Vol.36 pp432-3; author reply 434
  
• Differential killing of mismatch repair-deficient and -proficient cells: towards the therapy of tumors with microsatellite instability
  Cejka, P. Marra, G. Hemmerle, C. Storchova, Z. Jiricny, J.
  in Cancer Res (2003) Vol.63 pp8113-7
  
• Mismatch repair-dependent transcriptome changes in human cells treated with the methylating agent N-methyl-n’-nitro-N-nitrosoguanidine
  di Pietro, M. Marra, G. Cejka, P. Menigatti, M. Cattaruzza, M. S. Jiricny, J.
  in Cancer Res (2003) Vol.63 pp8158-66
  
• Methylation-induced G(2)/M arrest requires a full complement of the mismatch repair protein hMLH1
  Cejka, P. Stojic, L. Mojas, N. Heinimann, K. Cannavo, E. di Pietro, M. Marra, G. Jiricny, J.
  in EMBO J (2003) Vol.22 pp2245-54
  
• Dissection of the functions of the Saccharomyces cerevisiae RAD6 postreplicative repair group in mutagenesis and UV sensitivity
  Cejka, P. Vondrejs, V. Storchova, Z.
  in Genetics (2001) Vol.159 pp953-63