Geiger Roger, PhD

Systems Immunology
Group Leader

Via Vela, 6
6500 Bellinzona, Switzerland

Bio

Roger Geiger obtained his Master’s degree in biochemistry from the ETH Zürich in 2007. During his PhD studies at the ETH Zürich with Prof. Ari Helenius, Roger Geiger studied how non-enveloped viruses penetrate the host cell membrane. In 2011, Roger Geiger joined the laboratory of Prof. Antonio Lanzavecchia at the IRB and received a transition postdoc fellowship from SystemsX. The focus of his research was on metabolic regulations during the T cell response. In 2016, Roger Geiger joined the research group of Prof. Matthias Mann at the Max Planck Institute of Biochemistry in Munich and received training in mass spectrometry-based proteomics. In August 2017, Dr. Geiger started his own independent research group at the Institute for Research in Biomedicine to study T cell responses to tumors using systems biology techniques.

Publications -> 20814

Deciphering and predicting CD4+ T cell immunodominance of influenza virus hemagglutinin
Cassotta, A. Paparoditis, P. Geiger, R. Mettu, R. R. Landry, S. J. Donati, A. Benevento, M. Foglierini, M. Lewis, D. J. M. Lanzavecchia, A. Sallusto, F.
in J Exp Med (2020) Vol.217 pp
Dynamics in protein translation sustaining T cell preparedness
Wolf, T. Jin, W. Zoppi, G. Vogel, I. A. Akhmedov, M. Bleck, C. K. E. Beltraminelli, T. Rieckmann, J. C. Ramirez, N. J. Benevento, M. Notarbartolo, S. Bumann, D. Meissner, F. Grimbacher, B. Mann, M. Lanzavecchia, A. Sallusto, F. Kwee, I. Geiger, R.
in Nat Immunol (2020) Vol.8 pp927-937
The internal region of CtIP negatively regulates DNA end resection
Howard, S. M. Ceppi, I. Anand, R. Cejka, P.
in Nucleic Acids Res (2020) Vol. pp
A single T cell epitope drives the neutralizing anti-drug antibody response to natalizumab in multiple sclerosis patients
Cassotta, A. Mikol, V. Bertrand, T. Le Parc, J. Ferrari, P. Dumas, J. Auer, M. Deisenhammer, F. Gastaldi, M. Franciotta, D. Silacci-Fregni, C. Fernandez Rodriguez, B. Giacchetto-Sasselli, I. Foglierini, M. Jarrossay, D. Geiger, R. Sallusto, F. Lanzavecchia, A. Piccoli, L.
in Nat Med (2019) Vol.25 pp1402-1407
Plasma cell deficiency in human subjects with heterozygous mutations in Sec61 translocon alpha 1 subunit (SEC61A1)
Schubert, D. Klein, M. C. Hassdenteufel, S. Yang, L. Proietti, M. Bulashevska, A. Kemming, J. Kuhn, J. Winzer, S. Rusch, S. Fliegauf, M. Schaffer, A. A. Pfeffer, S. Geiger, R. Cavalie, A. Cao, H. Yang, F. Li, Y. Rizzi, M. Eibel, H. Kobbe, R. Marks, A. L. Peppers, B. P. Hostoffer, R. W. Puck, J. M. Zimmermann, R. Grimbacher, B.
in J Allergy Clin Immunol (2017) Vol.141 pp1427-1438
Social network architecture of human immune cells unveiled by quantitative proteomics
Rieckmann, J. C. Geiger, R. Hornburg, D. Kveler, K. Jarrossay, D. Sallusto, F. Shen-Orr, S. S. Lanzavecchia, A. Mann, M. Meissner, F.
in Nat Immunol (2017) Vol.18 pp583-593
L-Arginine Modulates T Cell Metabolism and Enhances Survival and Anti-tumor Activity
Geiger, R. Rieckmann, J. C. Wolf, T. Feng, Y. Fuhrer, T. Kogadeeva, M. Picotti, P. Meissner, F. Mann, M. Zamboni, N. Sallusto, F. Lanzavecchia, A.
in Cell (2016) Vol.167 pp829-842 e13
Geiger R. and Lanzavecchia A are co-corresponding authors.
Platelet-derived growth factor-alpha receptor is the cellular receptor for human cytomegalovirus gHgLgO trimer
Kabanova, A. Marcandalli, J. Zhou, T. Baxa, U. Tsybovsky, Y. Lilleri, D. Silacci-Fregni, C. Foglierini, M. Fernandez-Rodriguez, B. M. Druz, A. Zhang, B. Geiger, R. Pagani, M. Sallusto, F. Kwong, P. D. Corti, D. Lanzavecchia, A. Perez, L.
in Nat Microbiol (2016) Vol.1 pp16082
Anna Kabanova, Jessica Marcandalli, Tongqing Zhou equally contributed to this work; Antonio Lanzavecchia1and Laurent Perez jointly supervised this work.
A LAIR1 insertion generates broadly reactive antibodies against malaria variant antigens
Tan, J. Pieper, K. Piccoli, L. Foglierini, M. Geiger, R. Tully, C. M. Jarrossay, D. Ndungu, F. M. Wambua, J. Bejon, P. Fregni, C. S. Fernandez-Rodriguez, B. Barbieri, S. Bianchi, S. Marsh, K. Thathy, V. Corti, D. Sallusto, F. Bull, P. Lanzavecchia, A.
in Nature (2016) Vol.529 pp105-9
Joshua Tan, Kathrin Pieper, Luca Piccoli equally contributed to this work and Peter Bull and Antonio Lanzavecchia jointly supervised this work.

Geiger Roger, PhD

Bio

Publications -> 20814

Institute for Research in Biomedicine

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